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８名健康男性受试者连续６ｄ多剂量交叉口服萘普生缓释片和普通片的药代动力学和相对生物利用度研究。结果表明：萘普生缓释片和普通片的Ｔｍａｘ分别为３．５ｈ和１．３ｈ，表明缓释效果明显；经统计分析，萘普生缓释片（５００ｍｇ，ｑｄ）与萘普生普通片（２５０ｍｇ，ｂｉｄ）生物等效；萘普生缓释片的相对生物利用度为９７．０％；２种制剂的其他药代动力学参数如Ｃｍａｘ、Ｃｍｉｎ、ＡＵＣ２４０、ＡＵＣ∞０、ｔ１／２以及波动系数（ＦＩ）等均无显著性差异。
Pharmacokinetics and Relative Bioavailability of Naproxen Sustained-release Tablets and Common Tablets in 8 Healthy Male Subjects for Continuous 6d Multiple Dose Crossing. The results showed that the Tmax of naproxen sustained-release tablets and ordinary tablets were 3.5h and 1.3h, respectively, indicating that the sustained-release effect was obvious. According to statistical analysis, naproxen sustained release tablets (500mg, qd) The relative bioavailability of naproxen sustained-release tablets was 97.0%. Other pharmacokinetic parameters such as Cmax, Cmin, AUC240, AUC∞0, t1 / 2 and the coefficient of variation (FI), etc. There was no significant difference.