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报道了二羟基乙二肟（DHG）高剂量时可诱发小鼠初级精母细胞染色体畸变，小鼠精子畸形率升高，对孕鼠和胚胎有毒作用，可引起孕鼠体重减轻、流产、胚胎死亡，活胎生长发育迟缓，腭裂，胎鼠畸形，下颌缺失等，致畸指数为12；病理组织检查显示：雄鼠睾丸曲细精管生精细胞层次紊乱，生精细胞减少并可见多核巨精细胞；电镜可见，雌鼠卵巢黄体细胞浆内线粒体肿大，嵴减少，基质空泡变，出现髓鞘样结构，这些结果表明高剂量的DHG对雄性和雌性大鼠或小鼠都有生殖毒性。
Reported that dihydroxyethyleneglyoxime (DHG) at high doses can induce chromosome aberrations in primary spermatocytes in mice, mouse sperm abnormality rate increased, toxic effects on pregnant rats and embryos, can cause weight loss in pregnant rats, abortion, embryos Death, growth retardation of live fetus, cleft palate, fetus malformation, mandibular loss, teratogenic index of 12; histopathological examination showed: male rats testicular seminiferous tubule spermatogenic disorder, reduced spermatogenic cells and visible nuclear The results showed that the mitochondria of luteal cells in the ovary of female rats were swollen, the cristae were reduced and the matrix vacuolation was changed. The myelin-like structure appeared. These results indicated that high doses of DHG had the effects on both male and female rats or mice toxicity.