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目的探讨C反应蛋白(CRP)及胆红素水平与颈动脉粥样硬化程度的关系.方法原发性高血压患者90名,按颈动脉超声检测结果分为无斑块组和斑块组,将斑块组按回声强弱分为强回声组、弱回声组及混合回声组,比较各组间的CRP及胆红素.结果颈动脉粥样斑块随着回声增强,血清CRP水平增高,无斑块组和斑块组有显著差异(P<0.05),而斑块组间也有显著差异(P<0.05);斑块组血清胆红素水平低于无斑块组,无斑块组和斑块组有显著差异(P<0.05),但斑块组间无显著差异(P<0.05).结论原发性高血压患者颈动脉粥样硬化程度与CRP密切相关,颈动脉粥样斑块形成可能与低血清胆红素有关.“,” Objective To explore the association of C-reactive protein and serum bilirubin with carotid athersclerosis in patients with primary hypertension.Method 90 patients with primary hypertension whose carotid arteries were detected by ultrasound were divided into non-atheroma group and atheroma group.The atheroma group which detected by the grade of the ultrasound of the atheroma were divided into weak group,mixed group and hard group.Their serum c-reactive protein and serum bilirubin levels were measured and compared.Results Th ose with higher levels of serum c-reactive protein and lower serum bilirubin showed more severe carotid arthersclerosis(P<0.05).And C-reactive protein were different among the atheroma group (P0.05).Conclusions Serum C-reactive protein levels might be closely related to athersclerosls and the fomation of carotid plaque might be related to low levels of serum bilirubin.