小鼠胸腺髓质CD4~+CD8~-Qa-2~-细胞与小鼠胸腺髓质上皮细胞系(MTEC1)共育3d后,85％以上的细胞表达Qa-2抗原,明显高于MTEC1培养上清的诱导作用;抗LFA-1/ICAM一1对MTEC1诱导Qa-2表达的作用无影响;在MTEC1存在下,CD4~+CD8~-Qa-2~-细胞对Con A刺激应答及诱导其合成细胞因子的能力与CD4~+CD8~-Qa-2~+细胞比较,已无明显差异(p>0.05),即MTEC1能通过细胞间的直接相互作用诱导胸腺髓质CD4~+CD8~-Qa-2~-胸腺细胞表达Qa-2,并促进其功能分化。 After co-cultured with mouse thymic medulla epithelial cell line (MTEC1) for CD4 ~ + CD8 ~ -Qa-2 ~ - cells in the thymus medulla for more than 85%, more than 85% of cells expressed Qa-2 antigen, which was significantly higher than that of MTEC1 The effect of anti-LFA-1 / ICAM-1 on the expression of Qa-2 induced by MTEC1 was not affected. In the presence of MTEC1, CD4 ~ + CD8 ~ -Qa ~ 2 ~ Compared with CD4 ~ + CD8 ~ -Qa-2 ~ + cells, there was no significant difference between them (p> 0.05). MTEC1 can induce thymus medulla CD4 ~ + CD8 ~ -Qa-2 ~ - Thymocytes express Qa-2 and promote their functional differentiation.