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采用酶联免疫吸附法（ＥＬＩＳＡ）对１１２例延边地区朝鲜族原发性肝癌（ＰＨＣ）患者血清进行了乙型、丙型和丁型肝炎病毒（ＨＢＶ、ＨＣＶ和ＨＤＶ）的检测。结果，ＰＨＣ组ＨＢＶ、ＨＣＶ感染率显著高于对照组，ＯＲ值分别为２２．３３和６．２０；合并ＨＢＶ、ＨＣＶ混合感染的ＯＲ值为８５．８７，其相对超额危险度为３６．３１。其中６１例ＨＢｓＡｇ阳性肝癌的ＨＤＶ血清标志检出率２６．２２％，明显高于６５例ＨＢｓＡｇ阳性的肝炎对照组。提示ＨＢＶ、ＨＣＶ感染在朝鲜族ＰＨＣ的发生中有显著的病因协同作用；且ＨＢＶ、ＨＤＶ的混合感染可能促进肝脏疾病的恶化
Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum of hepatitis B, hepatitis C, and hepatitis D virus (HBV, HCV, and HDV) in 112 patients with Korean primary liver cancer (PHC) in Yanbian area. As a result, the HBV and HCV infection rates were significantly higher in the PHC group than in the control group, the OR values were 22.33 and 6.20, respectively; the OR value of the combined HBV and HCV infection was 85.87, and the relative excess risk was 36.31. . The detection rate of HDV serum markers in 61 cases of HBsAg-positive liver cancer was 26.22%, which was significantly higher than that of 65 HBsAg-positive hepatitis control groups. It is suggested that HBV and HCV infection have significant etiological synergism in the occurrence of Korean PHC; and mixed infection of HBV and HDV may promote the deterioration of liver disease.