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透明细胞肾细胞癌(ccR CC)是成年人中最为常见的肾肿瘤,并且它的发病率持续性增加。胶原蛋白在基质中是最丰富的细胞外基质蛋白,并且有助于ccR CC的发展和恶化。最近,有研究人员调查了人类胶原蛋白类型XXIIIα1链(COL23A1)在ccR CC中的表达以及COL23A1与病人生存率之间的关系。研究发现,与邻近的正常组织相比,COL23A1 mRNA在肿瘤组织中表达提高,该现象在TCGA队列中进一
Clear cell renal cell carcinoma (ccRCC) is the most common renal tumor in adults and its incidence continues to increase. Collagen is the most abundant extracellular matrix protein in the matrix and contributes to the development and worsening of ccR CC. Recently, researchers investigated the expression of the human collagen type XXIII alpha 1 chain (COL23A1) in ccRCC and the relationship between COL23A1 and patient survival. The study found that, compared with the adjacent normal tissue, COL23A1 mRNA expression in tumor tissue increased, the phenomenon into the TCGA cohort