气道平滑肌上存在多种钾通道,它们决定膜的静息电位,超极化细胞膜,复极化动作电位。ATP敏感性钾通道是其中重要的一种钾通道。ATP敏感性钾通道开放剂(KATPCOs)通过降低气道高反应性、抑制神经反射和递质释放等机制舒张气道平滑肌。新一代高选择性的KATPCOs副作用少,是较为有希望的哮喘治疗药。 There are a variety of potassium channels on airway smooth muscle, which determine the resting potential of the membrane, hyperpolarized cell membrane, repolarization action potential. ATP-sensitive potassium channel is one of the important potassium channels. ATP-sensitive potassium channel openers (KATPCOs) relax the airway smooth muscle by reducing airway hyperresponsiveness, inhibiting reflexes and releasing neurotransmitters. A new generation of highly selective KATPCOs has few side effects and is a promising therapeutic drug for asthma.