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1例75岁男性患者因肺部感染给予静脉滴注盐酸氨溴索葡萄糖注射液50 ml(含盐酸氨溴索30 mg及葡萄糖2.5 g)。约30 min后,患者突发胸闷、冷汗、恶心、头晕。体格检查:血压40/0 mm Hg(1 mmHg=0.133 kPa),口唇发绀,面色苍白,四肢冷,意识模糊。立即停止静脉滴注,行心电监护,并给予吸氧及地塞米松、异丙嗪、多巴胺等药物治疗。4 h后患者血压平稳,130/70 mm Hg,其余生命体征正常,症状消失。住院2周期间,未再静脉滴注盐酸氨溴索葡萄糖注射液,未再发生类似反应。
A 75-year-old male patient was given an intravenous infusion of 50 mg ambroxol hydrochloride (containing 30 mg ambroxol hydrochloride and 2.5 g glucose) for lung infections. About 30 min later, the patient burst chest tightness, cold sweat, nausea, dizziness. Physical examination: blood pressure 40/0 mm Hg (1 mmHg = 0.133 kPa), cyanotic lips, pale, cold limbs, confusion. Immediately stop intravenous infusion, ECG monitoring, and given oxygen and dexamethasone, promethazine, dopamine and other drug treatment. After 4 hours, the patient’s blood pressure was stable, with 130/70 mm Hg. The remaining vital signs were normal and the symptoms disappeared. During the two weeks of hospitalization, ambroxol hydrochloride glucose injection was no longer administered intravenously, and no similar reaction occurred.