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目的研究细胞凋亡调节蛋白(Bcl-2及Bax)在狼疮肾炎(LN)患者肾组织的表达情况及与LN肾脏病理改变的关系。方法2003-012003-04对广西医科大学第一附属医院的44例活动期LN患者用免疫组化方法检测肾组织中Bcl-2、Bax的表达,观察它们与LN肾脏病理改变的关系。结果(1)LN肾小球Bcl-2及Bax表达均增高,与肾小球细胞增殖程度及增殖细胞核抗原(PCNA)阳性细胞数呈正相关。(2)LN肾间质Bcl-2表达增高,与间质炎症细胞浸润程度正相关。(3)LN肾小管Bax表达增高,与肾小管间质病变呈正相关。结论LN肾组织存在Bcl-2、Bax蛋白异常表达。Bcl-2高表达在LN肾小球细胞增殖及肾间质炎症细胞浸润过程中可能起重要作用。Bax在肾小管过度表达与肾小管间质病变有关。
Objective To study the expression of Bcl-2 and Bax in renal tissues of patients with lupus nephritis (LN) and its relationship with pathological changes of LN. Methods The expression of Bcl-2 and Bax in renal tissue was detected by immunohistochemistry in 44 patients with active LN at the First Affiliated Hospital of Guangxi Medical University from 2003 to 2012003-04. Results (1) The expressions of Bcl-2 and Bax in glomeruli of LN were increased, which were positively correlated with the proliferation of glomerular cells and the number of proliferating cell nuclear antigen (PCNA) positive cells. (2) The expression of Bcl-2 in LN renal interstitium was increased, which was positively correlated with the degree of interstitial inflammatory cell infiltration. (3) LN tubular Bax expression increased, and tubulointerstitial lesions was positively correlated. Conclusion There is abnormal expression of Bcl-2 and Bax in LN kidney tissue. Bcl-2 overexpression may play an important role in the proliferation of LN glomerular and infiltration of inflammatory cells in renal interstitium. Bax in tubule over-expression and tubulointerstitial lesions.