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目的:研究补肾活血颗粒治疗帕金森病(PD)的“减毒增效”临床疗效。方法:将120例PD患者随机分成治疗组60例和安慰剂对照组60例。其中治疗组服用补肾活血颗粒,对照组服用安慰剂,均为2次/天,两组均以美多巴等西药为基础治疗。以3个月为治疗观察期,采用双盲设计,之后带药随访6个月观察。以患者治疗前后症状的变化及美多巴的用量为评价指标。结果:补肾活血颗粒可显著减少PD患者汗多、便秘、排尿障碍等症状的发生,减少美多巴用量,减轻美多巴的副作用(P<0.05)。研究过程中未发现明显不良反应。结论:补肾活血颗粒治疗PD可以达到“减毒增效”的效果,且随着治疗时间的延长作用逐渐显现。
Objective: To study the clinical efficacy of “Bushen Huoxue Granule” in treating “Parkinson’s disease” (PD). Methods: One hundred and twenty PD patients were randomly divided into treatment group (60 cases) and placebo control group (60 cases). The treatment group took Bushen Huoxue granule, the control group took placebo, both were 2 times a day, and both groups were treated with western medicine such as Medopa. Three months for the treatment of observation period, using a double-blind design, followed by drug 6-month follow-up. To patients before and after treatment of symptoms and changes in the amount of mebendazole for the evaluation of indicators. Results: Bushen Huoxue Granule can significantly reduce the occurrence of symptoms such as sweat, constipation and voiding dysfunction in PD patients, reduce the dosage of metoprolol, and reduce the side effects of methdopa (P <0.05). No adverse reactions were found during the study. Conclusion: Bushen Huoxue Granule can achieve the effect of “attenuating and improving the efficiency” and can be gradually seen with the prolongation of treatment time.