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目的研究不同程度的子宫颈病变患者的人乳头瘤病毒(HPV)感染情况和HPV亚型分布。方法选取本院妇科门诊448例行宫颈活检结果有异常病例,根据病理分为炎症组88例,宫颈上皮内瘤变CIN I组108例,CINⅡ组97例,CINⅢ组90例,宫颈癌组65例。并对448例患者用检酸分子快速杂交技术进行HPV-DNA分型检测。结果 448例患者中有337例(75.2%)HPV检测呈阳性。HPV亚型感染频度由高到低前五位分别为16、58、33、52、18,单一HPV16型在5组中的感染率分别是5.6%、13.9%、28.9%、40.0%、53.8%,差异有统计学意义(P<0.05)。有≥2型同时感染者为68例,其中炎症组6例(6.8%),CIN I组21例(19.4%)、CINⅡ组21例(21.6%)、CINⅢ组18例(20.0%)、宫颈癌组12例(18.4%)。宫颈病变各组间差异无统计学意义,但各宫颈上皮内瘤变组与炎症组相比差异有统计学意义(P<0.05)。结论随着高危型HPV感染的阳性率升高,宫颈病变级别呈上升趋势。在妇科体检中应重视HPV的发生。
Objective To study the HPV infection and HPV subtypes in patients with different degrees of cervical lesions. Methods A total of 448 cervical biopsies from gynecology clinic of our hospital were retrospectively analyzed. Among them, 88 cases were classified into inflammation group, 108 cases with CIN I group, 97 cases with CINⅡ group, 90 cases with CIN Ⅲ group and 65 cases with cervical cancer group example. 448 cases of patients with rapid acid-fast hybridization HPV-DNA typing test. Results Of the 448 patients, 337 (75.2%) had positive HPV testing. The top five infection frequency of HPV subtype were 16, 58, 33, 52 and 18, respectively. The infection rates of single HPV16 in the five groups were 5.6%, 13.9%, 28.9%, 40.0% and 53.8 %, The difference was statistically significant (P <0.05). There were 68 patients with ≥2 type infection at the same time, including 6 cases (6.8%) in inflammatory group, 21 cases (19.4%) in CIN I group, 21 cases (21.6%) in CINⅡ group and 18 cases (20.0% Cancer group 12 cases (18.4%). There was no significant difference between the groups of cervical lesions, but there was significant difference between the cervical intraepithelial neoplasia group and the inflammation group (P <0.05). Conclusion As the positive rate of high-risk HPV infection increases, the grade of cervical lesions is on the rise. In gynecological examination should pay attention to the occurrence of HPV.