恶性滋养细胞肿瘤(绒毛膜上皮癌和恶性葡萄胎)是化学药物治疗取得突破的第一个实性肿瘤20年前绒毛膜上皮癌(下简称绒癌)还是一种“不治之症”,死亡率达90%以上。1956年 Li 及 Hertz 等首先报道用氨甲喋呤治疗转移性滋养细胞肿瘤获得完全缓解。继氨甲喋呤后又发现长春花硷,放线菌素 D 等药对该类肿瘤有效。本文主要综述国外二十年来在治疗滋养细胞肿瘤方面的进展。 Malignant gestational trophoblastic tumors (choriocarcinoma and malignant mole) are the first solid tumors that have undergone chemical therapy to have a breakthrough 20 years ago, choriocarcinoma, or an “incurable disease,” resulting in death Rate of more than 90%. In 1956, Li and Hertz first reported complete response to methotrexate in the treatment of metastatic trophoblastic tumors. Following methotrexate and found that vinca alkaloids D Actinomycin and other drugs of this type of tumor effective. This article mainly summarizes the foreign progresses in the treatment of trophoblastic tumors over the past two decades.