Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common malignant tumor worldwide. Liver resection is a curative treatment for HCC and can be safety performed by a minimally invasive procedure in all liver segments without size limitations (1,2).Nevertheless, some patients are diagnosed with HCC and portal vein tumor thrombosis (PVTT). According to the staging system of the Barcelona Clinic Liver Cancer (BCLC), patients with macrovascular invasion are staged as BCLC-C. For those patients, the prognosis is generally poor. However, the management of HCC with macrovascular invasion is still controversial. Indeed, recent studies proposed different surgical procedure such as one-stage resection or associating liver partition and portal vein ligation, with promising results (3-5).