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目的:观察盐酸洛美沙星盐水注射液与红细胞接触,是否产生溶血与凝集现象。方法:参照药理学实验方法学方法制备2%兔红细胞混悬液,加入不同剂量的受试药物的溶液,观察0.5、1、2、3小时各试管内红细胞是否出现全溶血、部分溶血及凝血现象。结果:受试药物在3小时内均未出现溶血及凝集现象。结论:盐酸洛美沙星盐水注射液(0.8mg/ml)对家兔红细胞无影响(既不引起溶血及凝集)。
Objective: To observe whether Lomefloxacin Hydrochloride Saline Injection is in contact with erythrocytes, and whether hemolysis or agglutination occur. Methods: According to the method of pharmacology experimental method, 2% rabbit erythrocyte suspension was prepared. Different doses of test drug solution were added to observe whether erythrocytes were completely hemolysis in each tube at 0.5, 1, 2 and 3 hours. And coagulation phenomenon. Results: Hemolysis and agglutination did not occur in 3 hours. CONCLUSION: Lomefloxacin hydrochloride saline injection (0.8 mg / ml) has no effect on rabbit erythrocytes (causing no hemolysis or agglutination).