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本文应用ＳＯＳ显色法研究了三种有机稀土化合物及其相应鳌合剂的抗诱变作用。抗坏血酸稀土、柠檬酸稀土及乙二胺四乙酸稀土浓度分别在０．５～２．５ｍｇ／ｍｌ、１～２Ｏｍｇ／ｍｌ及５～４Ｏｍｇ／ｍｌ时，对已知致癌物亚硝基胍和３，４—苯并芘诱导的ＳＯＳ反应具有抑制作用，且有较好的剂量效应关系。而单纯的螫合剂抗坏血酸抗诱变效果很好，柠檬酸显示微弱的抗诱变性，乙二胺四乙酸二钠则无抗诱变作用。
In this paper, SOS colorimetric method was used to study the anti-mutagenic activity of three organic rare earth compounds and their corresponding chelating agents. Rare earth ascorbate, rare earth citrate and ethylenediaminetetraacetic acid rare earth concentrations of 0.5 ~ 2.5mg / ml, 1 ~ 2Omg / ml and 5 ~ 4Omg / ml, known carcinogens nitrosoguanidine and 3 , 4-benzopyrene-induced SOS response with inhibition, and have a good dose-response relationship. However, the simple chelating agent ascorbic acid has a good anti-mutagenic effect, citric acid shows weak anti-mutagenicity, and ethylenediaminetetraacetic acid disodium has no anti-mutagenic effect.