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目的:探讨黄芪建中汤与经典三联方案治疗幽门螺杆菌感染临床疗效分析。方法:将2016年1月至2017年1月期间,我院消化科门诊及病房收治的幽门螺杆菌感染的患者80例随机分为两组,即经典三联方案治疗组和联合治疗组。经典三联治疗组40例,给予奥美拉唑、阿莫西林、和克拉霉素治疗14d。联合治疗组在三联治疗的基础上予以黄芪建中汤治疗。停药4周后进行尿素酶呼气试验,判断疗效,统计幽门螺杆菌的根除率。结果:两组治疗疗效的比较,差异有统计学意义(P<0.05)。疗程结束后随访4周后,行13C-尿素酶呼气试验,联合治疗组的转阴率为87.5%%,而经典三联治疗组的转阴率为70.00%,差异有统计学意义(P<0.05)。结论:黄芪建中汤治疗幽门螺旋杆菌感染治愈率和总的有效率明显优于经典三联药物治疗。随访4周后,其幽门螺旋杆菌杆菌的根除率较高,临床上值得广泛推广。
Objective: To investigate the curative effect of Huangqi Jianzhong Decoction and classic triple regimen in the treatment of Helicobacter pylori infection. Methods: Between January 2016 and January 2017, 80 patients with Helicobacter pylori infection admitted to the Department of Gastroenterology and Ward in our hospital were randomly divided into two groups: the classic triple therapy group and the combination therapy group. Forty patients in the classic triple therapy group were treated with omeprazole, amoxicillin, and clarithromycin for 14 days. The combined treatment group was treated with Astragalus Jianzhong Decoction on the basis of triple therapy. After 4 weeks of withdrawal, urease breath test was performed to determine the efficacy and calculate the eradication rate of Helicobacter pylori. Results: The curative effect of the two groups was statistically significant (P <0.05). Four weeks after the end of the course of treatment, 13 C-urease breath test was performed. The negative conversion rate of the combined treatment group was 87.5 %%, while the negative conversion rate of the classic triple therapy group was 70.00%, with significant difference (P < 0.05). Conclusion: The cure rate and total effective rate of Astragalus Jianzhong decoction in treating H. pylori infection are obviously superior to the classical triple therapy. After 4 weeks of follow-up, the eradication rate of Helicobacter pylori is high, which is worth widely popularizing.