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目的多囊卵巢综合征患者通过应用达英-35(CPA)联合二甲双胍治疗,降低高LH、高雄激素血症可降低患者的体重,改善高雄激素环境提高卵巢排卵功能。方法将存在高LH、高T的PCOS肥胖患者周期随机分为两组:A组直接应用CC/HMG/HCG促排卵治疗3周期;B组自月经周期第2天给予达英-351片/d(并指导合理饮食)21d3周期同时二甲双胍三餐后各500mg3周期后促排卵治疗方法同A组。观察两组体重指数、月经周期、基础体温、卵泡发育及内分泌变化。结果试验组月经周期、基础体温、卵泡发育及内分泌变化优于对照组(P<0.05)。结论达英-35联合二甲双胍降低LH、雄激素效果好,明显降低患者体重指数,改善患者的临床症状及体征,提高了促排卵治疗的成功率。
OBJECTIVE: To treat patients with polycystic ovary syndrome (PCOS) by combination of metformin and metformin, to reduce high LH and hyperandrogenism can reduce the body weight of patients and improve hyperandrogenism and ovulation. Methods The PCOS obesity patients with high LH and high T were randomly divided into two groups: A group received CC / HMG / HCG ovulation induction for 3 cycles; B group received Ying-351 tablet / d on the 2nd day of menstrual cycle (And guide a reasonable diet) 21d3 cycle while metformin after three meals each 500mg3 cycle ovulation induction treatment with the A group. Body mass index, menstrual cycle, basal body temperature, follicular development and endocrine changes were observed. Results The menstrual cycle, basal body temperature, follicular development and endocrine changes in the experimental group were better than those in the control group (P <0.05). Conclusion Combination of metformin and metformin can reduce the effect of LH and androgen, significantly reduce the body mass index, improve the clinical symptoms and signs of patients and improve the success rate of ovulation induction therapy.