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目的:研究左奥硝唑氯化钠注射液治疗口腔厌氧菌感染的临床效果。方法:回顾选取我院2016年4月至2017年6月接收的87例口腔厌氧菌感染患者资料,将采取左奥硝唑氯化钠注射液医治的47例患者设研究组,采取奥硝唑氯化钠注射液医治的40例患者设对照组,并对比两组医治效率与不良反应。结果:研究组无效、有效、显效、治愈及有效率分别为1(2.12%)例、3(6.38%)例、11(23.40%)例、32(68.08%)例、43(91.48%)例;对照组为2(5.00%)例、2(5.00%)例、12(30.00%)例、24(60.00%)例、36(90.00%)例,比较差异无统计学意义(P>0.05),但研究组不良反应总发生率0.00%显著低于对照组25.00%(P<0.05)。结论:奥硝唑与左奥硝唑的药动学特征相似,但是左奥硝唑氯化钠的胃肠不适、脑器质损害、运动失调等不良反应发生率更低,药物安全性高。
Objective: To study the clinical effect of left ornidazole and sodium chloride injection in the treatment of oral anaerobic infections. Methods: The data of 87 patients with oral anaerobic infections received in our hospital from April 2016 to June 2017 were retrospectively selected. Forty-seven patients treated with left ornidazole and sodium chloride injection were divided into study group, Forty patients treated with azole sodium chloride injection were given control group, and the two groups were compared with the treatment efficiency and adverse reaction. Results: The study group was ineffective, effective, effective and cured. The effective rates were 1 case (2.12%), 3 cases (6.38%), 11 cases (23.40%), 32 cases (68.08%) and 43 cases (91.48% cases) ; The control group had no significant difference between 2 (5.00%) cases, 2 (5.00%) cases, 12 (30.00%) cases, 24 (60.00%) cases and 36 (90.00% , But the overall incidence of adverse reactions in the study group 0.00% was significantly lower than the control group 25.00% (P <0.05). CONCLUSION: The pharmacokinetic characteristics of ornidazole and lemony ornidazole are similar. However, the incidence of adverse reactions such as gastrointestinal discomfort, damage of brain tissue and dyskinesia of left ornidazole and sodium chloride is lower and drug safety is higher.