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目的探讨城乡结合部老年人群估算肾小球滤过率(eGFR)的异常情况及其发生的危险因素,为延缓慢性肾脏病(CKD)的病程进展提供依据。方法采用横断面调查的方式,在2016年3—5月普查本社区60岁以上的户籍居民5 097名,收集相关体检指标,以2009年慢性肾病流行病学协作组(CKD-EPI)方程计算eGFR,并以eGFR≤60 ml/(min·1.73 m~2)为切点判断慢性肾脏病,应用SPSS 18.0统计软件进行统计,计算人群患病率并分析不同危险因素与疾病的关系。结果 60岁以上老年人平均eGFR为(77.44±19.16)ml/(min·1.73 m~2),同年龄段的性别间的eGFR_(CKD-EPI)水平比较,男性的eGFR_(CKD-EPI)平均值均低于女性,差异有统计学意义(P<0.01);CKD患病数为888人,患病率为17.42%,其eGFR均值为(49.40±9.92)ml/(min·1.73 m~2)。以10岁为间隔进行分组,结果显示,随着年龄上升,eGFR_(CKD-EPI)逐渐降低(P<0.01)。年龄、男性、高血压病和高尿酸是eGFR异常的危险因素(P<0.001)。结论 60岁以上老年人群的CKD患病率较高,尤其是高龄老人,需要关注社区老年人的肾脏疾病和相关危险因素。
Objective To investigate the anomalies of glomerular filtration rate (eGFR) and its risk factors in elderly people at the junction of urban and rural areas and to provide basis for delaying the progression of chronic kidney disease (CKD). Methods By means of cross-sectional survey, 5- 097 permanent residents over the age of 60 in this community were surveyed from March to May in 2016. The relevant physical examination indexes were collected and calculated according to the 2009 CKD-EPI equation eGFR, and the eGFR≤60 ml / (min · 1.73 m ~ 2) as the cut-off point to determine the chronic kidney disease, using SPSS 18.0 statistical software to calculate the prevalence of the crowd and analyze the relationship between different risk factors and the disease. Results The mean eGFR of the elderly over 60 years old was (77.44 ± 19.16) ml / (min · 1.73 m 2). The mean eGFR CKD-EPI of the same age group was The mean value of eGFR was (49.40 ± 9.92) ml / (min · 1.73 m ~ 2) in CKD patients with a prevalence of 17.42% ). Grouping at intervals of 10 years showed that eGFR_ (CKD-EPI) gradually decreased with age (P <0.01). Age, men, hypertension, and hyperuricemia were risk factors for eGFR abnormalities (P <0.001). Conclusion The prevalence of CKD in the elderly over 60 years old is high, especially for the elderly. It is necessary to pay attention to the kidney disease and the related risk factors of the elderly in the community.