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以往文献报道,羟氨喹治疗曼氏血吸虫病人几乎不出现副反应,但费用较高;而硝唑咪的费用虽低,但药物的副作用较多。本文比较了用羟氨喹(20mg/kg/d×3)和硝唑咪(15mg/kg/d×8)治疗单纯曼氏血吸虫病成人和儿童患者的疗效、临床副反应和实验室指标的变化。所有患者均住院治疗,并进行询问病史、体检、全血计数,肝、肾功能测定以及粪内虫卵计数。对治前每克粪便虫卵数在100个以上而无腹水或肝代偿失调的患者进行乙状结肠镜检查,以排除血吸虫性结肠息肉症。应用羟氨喹或硝唑咪治疗61例6～16岁的儿童和55例17～60岁的成人,记录治程中的药物副反应。于治后4、8和12周时重复虫卵
Previous literature reports, hydroxyquine treatment of Schistosoma mansoni almost no side effects, but the cost is higher; while the cost of nifedipine is low, but more side effects of drugs. This article compared the efficacy, clinical side effects, and laboratory parameters of adult and pediatric patients treated with hydroxyquramine (20 mg / kg / d × 3) and nadazole (15 mg / kg / d × 8) Variety. All patients were hospitalized, and asked for medical history, physical examination, whole blood count, liver and kidney function tests and fecal eggs count. Sigmoidoscopy was performed on sigmoidoscopy in patients with pre-treatment fecal egg count of 100 or more without ascitic or hepatic decompensation to rule out schistosomiasis. Sixty-one children aged 6-16 years and 55 adults aged 17-60 years were treated with hydroxyamil or nitazoxan, and the side effects were recorded. The eggs were replicated at 4, 8 and 12 weeks post-treatment