程序性死亡1(programme death 1,PD-1)受体和其配体B7-H1的生物学通路对免疫反应有重要的调节作用。PD-1受体主要表达于活化后的外周T细胞、B细胞及髓样细胞,分子结构类似于其他CD28/CTLA-4家族成员,目前认为其具有抑制T细胞反应等负性免疫调节作用;而B7-H1广泛表达于静息和活化状态的T The biological pathway of the program-death 1 (PD-1) receptor and its ligand B7-H1 plays an important regulatory role in the immune response. PD-1 receptor is mainly expressed in activated peripheral T cells, B cells and myeloid cells. The molecular structure of PD-1 receptor is similar to that of other CD28 / CTLA-4 family members. Currently, PD-1 receptor is considered to have negative immunomodulatory effects such as T cell responses. B7-H1 is widely expressed in resting and activated T cells