通过建立S180荷瘤小鼠试验动物模型,研究小刺猴头菌发酵浸膏寡糖对S180荷瘤小鼠免疫功能的影响。选择灌胃的方法将不同组别小刺猴头菌发酵浸膏寡糖喂服到荷瘤小鼠体内,观察肿瘤生长情况,对其进行免疫功能的测定。结果表明:小刺猴头菌发酵浸膏寡糖可增加荷瘤小鼠免疫器官脾脏和胸腺质量,提高荷瘤小鼠血清的IL-2和TNF-α含量,抑制肿瘤生长,提高机体免疫功能。 The establishment of S180 tumor-bearing mice experimental animal model to study the Hericium ermanii fermentation extract oligosaccharides on S180 tumor-bearing mice immune function. The method of intragastric administration was used to feed the different groups of Hericium eriniae fermented extract oligosaccharides to the tumor-bearing mice to observe the tumor growth and measure the immune function. The results showed that oligosaccharides of Hericium erinaceus could increase the spleen and thymus mass of immune organs in tumor-bearing mice and increase the levels of IL-2 and TNF-α in sera of tumor-bearing mice, inhibit the growth of tumor and enhance the immune function .