论文部分内容阅读
【目的】观察养阴益气法联合胰岛素泵强化治疗对改善气阴两虚型2型糖尿病患者胰岛素抵抗状态的疗效。【方法】将60例2型糖尿病气阴两虚型患者随机分为2组,每组各30例。治疗组给予胰岛素泵强化治疗加服养阴益气方(由太子参、葛根、麦冬、五味子、花粉、知母、黄芪、生地、玄参、丹参、山药、苍术组成),对照组单纯采用胰岛素泵强化治疗,疗程均为2周。观察2组临床综合疗效以及空腹血糖(FBG)、空腹胰岛素(FINS)、餐后2 h血糖(2 h PG)、血脂[总胆固醇(TC)、甘油三酯(TG)]、血液流变学(全血黏度、血浆黏度)、胰岛素抵抗指数(HOMA-IR)等指标的变化,记录胰岛素用量、血糖达标时间。【结果】2组临床综合疗效比较,差异无显著性意义(P>0.05),但在中医证候疗效方面,治疗组明显优于对照组(P<0.05)。治疗后2组的FBG、2 h PG、FINS、HOMA-IR均明显下降(与治疗前比较,P<0.05或P<0.01),但治疗组FINS、HOMA-IR的下降作用明显优于对照组(P<0.05)。治疗后2组的血脂和血液流变学指标均明显下降(与治疗前比较,P<0.01),但治疗后组间比较,差异均无显著性意义(P>0.05)。治疗过程中治疗组胰岛素平均用量较对照组少,血糖达标时间较对照组快(均P<0.05)。治疗过程中除了少数的低血糖反应,均未出现其他明显不良反应。【结论】养阴益气法联合胰岛素泵强化治疗对2型糖尿病气阴两虚型患者中医证候改善作用显著,且胰岛素用量减少,血糖达标更快、更平稳,低血糖发生次数更少。
【Objective】 To observe the effect of nourishing yin and qi method combined with insulin pump on insulin resistance in patients with type 2 diabetes of qi and yin deficiency. 【Methods】 Sixty patients with type 2 diabetes with qi and yin and deficiency of both qi and yin were randomly divided into 2 groups with 30 cases in each group. The treatment group was given insulin pump intensive treatment plus Yangyinyiqifang (composed of heterophylla, puerarin, Radix Ophiopogon japonicus, Schisandrae, pollen, Anemarrhena, Astragalus, Health, Scrophulariaceae, Salvia, yam, herb) Insulin pump intensive treatment, treatment are 2 weeks. The clinical efficacy, fasting blood glucose (FBG), fasting insulin (FINS), 2 h postprandial blood glucose (2 h PG), blood lipid [total cholesterol (TC), triglyceride (TG) (Whole blood viscosity, plasma viscosity), insulin resistance index (HOMA-IR) and other indicators of change, record the amount of insulin, blood glucose compliance time. 【Results】 There was no significant difference between the two groups in clinical efficacy (P> 0.05). However, in the treatment of TCM syndromes, the treatment group was significantly better than the control group (P <0.05). FBG, 2 h PG, FINS and HOMA-IR of the two groups after treatment were significantly decreased (P <0.05 or P <0.01 compared with those before treatment), but the decreasing effect of FINS and HOMA-IR in the treatment group was significantly better than that of the control group (P <0.05). After treatment, the levels of blood lipids and hemorrheology were significantly decreased in both groups (P <0.01 compared with those before treatment), but there was no significant difference between the two groups after treatment (P> 0.05). During the course of treatment, the average insulin dosage of the treatment group was less than that of the control group, and the time of reaching the blood glucose level was faster than that of the control group (all P <0.05). In addition to a small number of hypoglycemic reactions during treatment, no other obvious adverse reactions. 【Conclusion】 Nourishing Yin and Invigorating Qi combined with insulin pump therapy have significant effect on TCM syndromes in patients with type 2 diabetes with deficiency of both qi and yin. In addition, the dosage of insulin is reduced, the blood sugar is up-regulated faster and more smoothly, and the incidence of hypoglycemia is less.