论文部分内容阅读
目的探讨外周血白细胞(WBC)计数水平与回汉民族2型糖尿病(T2DM)之间的关系。方法采用病例-对照研究,于2011年10月至2012年10月在宁夏医科大学附属医院和吴忠市人民医院内分泌科住院患者及在门诊健康体检者中,按照纳入和排除标准,以性别、民族和年龄相差不超过3岁进行病例和对照的匹配,最终确定351例T2DM患者作为病例组和655例健康人群作为对照组,进行问卷调查(包括一般情况、生活方式、疾病及用药史、家族史)、体格检查[包括身高、体重、腰围(WC)、收缩压(SBP)和舒张压(DBP),并根据身高和体重计算体质指数(BMI)]以及实验室检测[包括甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、血尿酸(UA)、门冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)等血液生化指标]。结果糖尿病组平均年龄(50.28±8.32)岁,男性194例(55.27%),女性157例(44.73%);对照组平均年龄(50.17±7.14)岁,男性337人(51.45%),女性318人(48.55%);两组间平均年龄、性别构成比的差异均无统计学意义。糖尿病组外周血WBC水平[(6.66±1.61)×109/L]明显高于对照组[(6.11±1.49)×109/L],差异有显著性(t=-5.430,P<0.01),回族外周血WBC平均水平[(6.459±1.45)×109/L]与汉族[(6.169±1.63)×109/L]比较,差异有统计学意义(P<0.05);糖尿病组白细胞异常率为2.6%,对照组为0.8%,糖尿病组显著高于对照组(χ2=4.168,P=0.041);调整年龄、性别、民族、TG、TC、HDL、LDL、ALT、AST、血糖等因素后,外周血WBC异常人群糖尿病的发病风险是外周血WBC正常人群的4.072倍;调整年龄、性别、患病与否、TG、TC、HDL、LDL、ALT、AST、血糖等因素后,回族人群外周血WBC增高的风险是汉族人群的1.582倍。结论 WBC计数水平与2型糖尿病密切相关,并随其水平升高,这种关联逐渐增强,说明WBC参与了2型糖尿病的发生、发展。民族遗传因素与WBC计数水平存在一定的关系。
Objective To investigate the relationship between peripheral blood leukocyte count (WBC) and type 2 diabetes in Han and Hui patients (T2DM). Methods A case-control study was conducted between October 2011 to October 2012 in the hospitalized patients of Department of Endocrinology of Ningxia Medical University and Wuzhong People’s Hospital and in outpatient health examination. According to inclusion and exclusion criteria, sex, ethnicity 351 patients with T2DM were selected as the case group and 655 healthy people as the control group, and the questionnaires (including general conditions, lifestyle, disease and medication history, family history ), Physical examination (including height, weight, waist circumference (WC), SBP and DBP, and body mass index (TC), HDL-C, LDL-C, UA, AST, ALT, Other blood biochemical indicators]. Results The average age of the diabetic group was 50.28 ± 8.32 years, 194 cases were male (55.27%) and 157 cases were female (44.73%). The average age of the control group was (50.17 ± 7.14) years old, 337 males (51.45%), 318 females (48.55%). There was no significant difference in mean age and sex ratio between the two groups. The WBC level in the peripheral blood of diabetic group was significantly higher than that of the control group [(6.66 ± 1.61) × 109 / L vs (6.11 ± 1.49) × 109 / L, t = -5.430, P <0.01) The mean level of WBC in peripheral blood [(6.459 ± 1.45) × 109 / L] was significantly higher than that in Han [(6.169 ± 1.63) × 109 / L] (Χ2 = 4.168, P = 0.041). After adjustment for factors such as age, gender, nationality, TG, TC, HDL, LDL, ALT, AST and blood glucose, the peripheral blood The incidence of diabetes in WBC abnormal population is 4.072 times of the normal WBC in peripheral blood. After adjusting for age, gender, illness or not, TG, TC, HDL, LDL, ALT, AST, blood glucose and other factors, The risk is 1.582 times the Han Chinese population. Conclusion The WBC count is closely related to type 2 diabetes mellitus, and with the increase of the WBC count, this association is gradually enhanced, indicating that WBC is involved in the development of type 2 diabetes. There is a certain relationship between ethnic genetic factors and WBC count.