Expression of e-cadherin and β-catenin in human esophageal squamous cell carcinoma: relationships wi

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:snoopy_wx
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM:To elucidate the expression of E-cadherin and β-catenincorrelating with its clinical outcome in patients withesophageal squamous cell carcinoma(ESCC),by analyzingtheir interrelationship with clinicopathological variables andtheir effects on progress and prognosis.METHODS:Expression of E-cadherin and β-catenin wasdetermined by SP immunohistochemical technique inpatients with ESCC consecutively,their correlation withclinical characteristics was evaluated and analyzed bymultivariate analysis.RESULTS:The rate of expression of E-cadherin decreasedto 66.03 %(70/106)in ESCC and the protein level wasnegative correlated with histologic grade,tumor size,clinicalstaging,lymph node metastasis and venous invasion.Whereas the expression rate of β-catenin was reduced to69.8 %(74/106)and the level of protein expressioncorrelated only with histologic grade.There obviously existedinverse correlation between level of E-cadherin protein andsurvival,especially in stage Ⅰ,Ⅱa,Ⅱb(P=0.0033),Patientswith low-expressing tumors for β-catenin and non-expressingtumors for E-cadherin/β-catenin had lower survival periodthan those with normal-expressing ones(P=0.0501 andP=0.0080,respectively).Patients with diminished expressionof E-cadherin as grade Ⅱ or Ⅲ had shorter survival periodthan those with normally expressing and grade Ⅰ,nosignificance existed between grade Ⅰ and grade Ⅱ or Ⅲwith respect to different status of E-cadherin expression.Furthermore,Correlation analysis showed level of E-cadherincorrelated with that of β-catenin(P=0.005).Cox proportionalhazards model analysis suggested downregulation of E-cadherin was an important factor indicating poor prognosis.CONCLUSION:As a probable independent prognosticfactor,it correlates with overall and disease free survivalperiod,expression of E-cadherin but not β-catenin maypredict prognosis in patients with ESCC. AIM: To elucidate the expression of E-cadherin and β-catenincorrelating with its clinical outcome in patients withesophageal squamous cell carcinoma (ESCC), by analyzing their interrelationship with clinicopathological variables andtheir effects on progress and prognosis. METHODS: Expression of E-cadherin and β -catenin wasdetermined by SP immunohistochemical technique in patients with ESCC consecutively, their correlation with clinical characteristics was evaluated and analyzed by multivariate analysis .RESULTS: The rate of expression of E-cadherin decreased to 66.03% (70/106) in ESCC and the protein level wasnegative correlated with histologic grade, tumor size, clinicalstaging, lymph node metastasis and venous invasion. Here the expression rate of β-catenin was reduced to 69.8% (74/106) and the level of protein expressioncorrelated only with histologic grade. There was actually an inverse correlation between level of E-cadherin protein andsurvival, especially in stage I, IIa, IIb (P = 0.0033), Patien tswith low-expressing tumors for β-catenin and non-expressing tumors for E-cadherin / β-catenin had lower survival period with normal-expressing ones (P = 0.0501 and P = 0.0080, respectively). Patients with diminished expression of E-cadherin as grade II or III had shorter survival period with those with normally expressing and grade I, nosignificance existed between grade I and grade II or III with respect to different status of E-cadherin expression. Focus on, Correlation analysis showed level of E-cadherincorrelated with that of β -catenin (P = 0.005). Cox proportional hazards models analysis suggested downregulation of E-cadherin was an important factor indicating poor prognosis. CONCLUSION: As a probable independent prognostic factor, it correlates with overall and disease free survivalperiod, expression of E-cadherin but not β-catenin maypredict prognosis in patients with ESCC.
其他文献
根据史书记载,《千字文》是南朝梁武帝在位时期(502—549年)编著而成的,其编者是梁朝散骑侍郎周兴嗣(?—521年,梁朝陈郡项河南沈丘人)。据唐代李倬《尚书故实》记载,梁武帝命
在“普高热”的主流形势下,不少中职学校不得不在生源遭遇重点高中、普通中学等筛选后再次降低入学门槛。不少学生到校后目标不明确,积极性不高,不思进取。更有不少学生染有
由中国岩石矿物地球化学学会矿物包裹体专业委员会、南京大学内生金属矿床成矿机制国家开放实验室、中同科学院贵阳地球化学研究所矿床地球化学重点实验室主办,国际矿物协会
当前市场经济环境下,社会各层面对技术类人才的需求尤为突出。这对高职院校学生的深入实践和解决实际问题的能力提出了新的要求。而教师是课堂教学过程的主导。本文结合高职
详细叙述了偏心定位销的工艺方法。该定位销可解决两部件同铰加工的困难,尤其对大部件的同心联接提供了方便。 Described in detail the eccentric positioning pin technol
www.irla.cn Since its publication in 1972,Infrared and Laser Engineering,the journal of Professional Association of Photo-electronic Technology, Chinese Society
期刊
不其簋上所铸铭文内容丰富,极具史料价值,能够与相关传世文献相互印证,辅证史实。多年来学界诸多大家都对不其簋上所记内容的时代,人物身份等做过推测或是考证,例如郭沫若先
要发展就需要对应的人才来设计和规划,所以为了适应农机的发展,跟上前进的脚步,就需要加快人才的输出,最根本最有效的方法就是改革高职教育。只有改变了教学模式,才能彻底改
本文所指的中、小型水电设备是指水轮机、发电机、阀门等设备,其价格是指制造厂家交付用户的出厂价。通常,在进行水电站设计时,由于缺少机组设备价格资料,很难估算电站的投
在我国中职学校的音乐教学中普遍存在重理论、技能而轻实践应用的问题。而声乐教学在整个音乐教学中占有非常重要的地位。现行的教学模式已不能适应当前社会的变革和经济发展