目的：探讨冠脉介入造影剂对不同肾功能患者的影响，并分析围术期水化疗法整体护理对造影剂肾病(CIN)的治疗效果。方法将838例接受冠状介入患者作为观察对象，根据术前肾功能将患者分为539例肾功能正常的A组及299例肾功能不全的B组，对比两组术后24小时内CIN的发生率。同时随机将A组分为A1组与A2组，将B组B1组与B2组。A1组及B1组围术期接受水化常规护理，而A2及B2组围术期接受水化整体护理。分别对比A1组与A2组及B1组与B2组治疗前后肾功能变化情况。结果B组CIN发生率18.00％，明显高于A组的4.60％(P<0.05)。同时A1组与A2组间及B1组与B2组间术前血清肌酐（Cr）及尿素氮（BUN）比较未见统计学差异，而术后24h后，A2组Cr及BUN升高明显低于A1组，B2组Cr及BUN升高同样明显低于B1组(P<0.05)。结论肾功能不全者接受冠脉介入造影后更易发生CIN，而整体化水化疗法护理可有效的改善患者术后肾脏功能。“,”Objective On patients with coronary intervention contrast agents for different renal function, and analysis of perioperative hydration therapy of overall nursing in the treatment of contrast nephropathy (CIN).Methods To 838 patients who underwent coronary intervention in patients as research object, according to the preoperative renal patients divided into 539 cases of normal renal function in group A and group B, 299 cases of renal insufficiency, compared two groups the incidence of CIN in 24 hours after surgery. At the same time A set of random divided into A1 and A2 group, group B group B1 and B2. A1 and B1 group perioperative accept hydration routine nursing care, and A2 and B2 received perioperative hydration holistic nursing. Respectively compared to the group of A1 and A2 and B1 and B2 group renal function changes before and after the treatment.Results Group B the incidence of CIN was 18.00%, significantly higher than the 4.60%of the group A (P<0.05). Between A1 and A2 group and between B1 and B2 group preoperative serum creatinine (Cr) and urea nitrogen (BUN) was no statistical difference, and after 24 h after surgery, A2 set of Cr and elevated BUN was lower than that in group A1, B2 Cr and BUN increased significantly lower than the same B1 group (P<0.05).Conclusion Renal insufficiency who accept are more likely to happen after coronary intervention imaging CIN, integrative hydration therapy and nursing can effectively improve the patients postoperative renal function.