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目的观察大剂量静脉注射人血免疫球蛋白(intravenous immune globulin,IVIG)治疗吉兰-巴雷综合征(GBS)的临床疗效。方法回顾性分析39例GBS患者的临床资料,其中IVIG治疗组28例,按体质量0.4g/(kg·d)给予IVIG治疗,疗程5～20 d,平均(9.43±4.96)d;糖皮质激素治疗组11例,给予地塞米松10～20mg/d治疗,10 d后逐渐减量。比较两组患者治疗效果,同时对IVIG治疗的起始时间、疗程及发病严重程度与疗效的关系进行相关分析。结果 IVIG治疗组疗效明显优于糖皮质激素治疗组(P<0.05);IVIG用药起始时间(r=-0.441,P<0.05)、疗程(r=0.403,P<0.05)及发病严重程度(r=0.576,P<0.05)与疗效具有相关性。结论 IVIG治疗GBS疗效优于糖皮质激素治疗,早期、足量、足疗程行IVIG治疗对GBS患者疗效至关重要。
Objective To observe the clinical effect of intravenous injection of intravenous immune globulin (IVIG) on Guillain-Barre syndrome (GBS). Methods The clinical data of 39 patients with GBS were retrospectively analyzed. Among them, 28 patients were treated with IVIG at a dose of 0.4 g / (kg · d) for IVIG for 5-20 days (average, 9.43 ± 4.96) days. Glucocorticoids Eleven patients in the hormone therapy group were treated with dexamethasone 10 ~ 20mg / d, and gradually reduced after 10 days. The curative effect of the two groups was compared, and the relationship between the onset time of IVIG treatment, the course of treatment, the severity of the disease and the curative effect was analyzed. Results The IVIG treatment group was significantly better than glucocorticoid treatment group (P <0.05); IVIG medication start time (r = -0.441, P <0.05) r = 0.576, P <0.05) and the effect is related. Conclusion The efficacy of IVIG in treatment of GBS is better than that of glucocorticoid therapy. IVIG treatment of early, adequate and full course of treatment is very important for the curative effect of GBS.