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目的探讨光动力联合替吉奥治疗老年胃癌的临床疗效及不良反应。方法选择2013年1月至2014年10月间淄博市第四人民医院诊治的64例老年胃癌患者,根据随机数字法分为对照组(光动力)和观察组(光动力联合替吉奥),每组各32例。根据实体瘤疗效评价标准评定两组患者治疗后的临床疗效,根据国际肿瘤化疗药物不良反应评价系统标准评定两组患者治疗期间的不良反应。结果与对照组相比,观察组患者的治疗总有效率明显提高(P<0.05);两组患者治疗期间不良反应发生率的差异无统计学意义(P>0.05)。结论光动力联合替吉奥治疗老年胃癌的疗效显著,并且不良反应少,患者能够较好地耐受,值得临床推广。
Objective To investigate the clinical efficacy and adverse reactions of photodynamic therapy combined with tirofibrate in the treatment of elderly patients with gastric cancer. Methods Sixty-four elderly gastric cancer patients diagnosed and treated in Zibo Fourth People’s Hospital from January 2013 to October 2014 were randomly divided into control group (PDT) and observation group (PDT) 32 cases in each group. According to the evaluation criteria of solid tumor efficacy evaluation of two groups of patients after treatment of clinical efficacy, according to the International Tumor Chemotherapy Drug Adverse Reaction Evaluation System standard assessment of two groups of patients during treatment of adverse reactions. Results Compared with the control group, the total effective rate of patients in the observation group was significantly increased (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The combination of photodynamic therapy and tegaserod is effective in the treatment of elderly patients with gastric cancer and has few adverse reactions. The patients are well tolerated and worthy of clinical promotion.