经过探讨母体化合物及目标化合物的合成路线，设计合成了６个新化合物．经元素分析和光谱解析，确证了其结构是正确的，通过动物筛选实验，发现大部分目标化合物照前腹腔给药，都有一定程度的辐射防护作用，其中Ａ００６抗辐射作用明显，提高活存率４７３％，研究证明，六员环状双硫结构稳定且保持了抗辐射作用的基本结构． After exploring the synthesis of the parent compound and the target compound, six new compounds were designed and synthesized. Through the elemental analysis and spectral analysis, it was confirmed that the structure was correct. Through animal screening experiments, most of the target compounds were found to be administered intraperitoneally before irradiation, and there was a certain degree of radioprotective effect. The A006 had a significant anti-radiation effect and increased the viability Rate of 47  3%, studies have shown that six-member cyclic disulfide structure is stable and maintain the basic structure of anti-radiation effect.