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目的:评价纳洛酮配合血液透析对急性重度乙醇中毒患者解毒功效。方法:选取2013年8月—2016年3月收治的急性重度乙醇中毒患者106例,按照随机双盲法将患者分为治疗组与参照组,每组53例;参照组患者给予纳洛酮治疗,治疗组患者在对照组治疗基础上加用血液透析治疗,比较两组患者治疗后的总有效率和并发症发生情况。结果:治疗组患者临床治疗后的总有效率为98.11%高于对照组为77.36%(P<0.05);治疗组患者治疗后意识复常时间、症状消失时间均短于对照组(P<0.05),并发症的发生率低于对照组(P<0.05)。结论:纳洛酮配合血液透析对急性重度乙醇中毒患者解毒疗效优于单用纳洛酮治疗,可加快患者意识复常和症状消失。
OBJECTIVE: To evaluate the efficacy of naloxone with hemodialysis in detoxifying patients with acute severe alcoholism. Methods: A total of 106 acute severe alcohol poisoning patients were enrolled from August 2013 to March 2016. Patients were divided into treatment group and reference group according to a randomized double-blind method, with 53 patients in each group. Patients in reference group were treated with naloxone The patients in the treatment group were treated with hemodialysis on the basis of the control group, and the total effective rate and complications after treatment were compared between the two groups. Results: After treatment, the total effective rate of the treatment group was 98.11%, which was significantly higher than that of the control group (77.36%, P <0.05). The recovery time of consciousness and the disappearance of symptoms in the treatment group were shorter than those in the control group ), The incidence of complications was lower than that of the control group (P <0.05). Conclusion: Naloxone combined with hemodialysis is superior to Naloxone alone in detoxification of patients with acute severe alcoholism, which can speed up patients’ consciousness and disappearance of symptoms.