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对乙酰氨基酚( APAP)是乙酰苯胺类药物，为非那西丁代谢产物，因其常用剂量安全有效，是临床上常用的解热镇痛药。近期，美国食品药品管理局( FDA)对于APAP肝毒性的警示再次引起了公众对APAP安全性的严重关注。 APAP过量使用或与酒精同时服用而引起药物性肝损害时见报道，含有APAP成分的抗感冒药物超量服用或联合使用尤其应避免。该文就APAP肝毒性发生机制、使用剂量、肝毒性的预防和救治进行综述，以促进和规范APAP的安全合理使用。“,”Acetaminophen(APAP) is an antipyretic analgesic with acetanilide structure,which is the major metabolite of phenacetin. Because of the safe dose of APAP,it is a common antipyretic analgesic drug in clinical. The recent warning of APAP hepatotoxicity by FDA aroused public great concern on APAP safety once again. Drug-induced liver damage is often reported because of excessive APAP use or combined uptake with alcohol,APAP overdoses or in combination should be avoided. Here is to make a review of the occur-rence mechanism of APAP hepatotoxicity,dosage,prevention and treatment of hepatotoxicity,in order to pro-mote the rational and safe use of APAP.