抗高血压制剂氯压定和α-甲基多巴被认为是通过中枢神经机理而产生其心血管效应。氯压定在中度原发性高血压患者的降低血压和心率,约半数可被注射纳洛腙(naloxone)所迅速逆转,而其余患者则无作用。为试图分析上述效应的不同和澄清肾上腺素能-类鸦片相互作用的机理,作者在无并发症的原发性高血压患者中检查氯压定、纳洛腙及其联合所产生的血流动力学和生化改变。 Antihypertensive agents Clonazepam and alpha-methyl dopa are thought to exert their cardiovascular effects through the central nervous system. Clonazepam reduces blood pressure and heart rate in patients with moderate essential hypertension, with about half of them being rapidly reversed by injection of naloxone, while the rest have no effect. In an attempt to analyze the differences in these effects and to clarify the mechanism of adrenergic-opioid interactions, the authors examined the effects of clonidine, naloxone and their combination on hemodynamics in patients with uncomplicated essential hypertension Learning and biochemical changes.