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目的检测乙型肝炎病毒(HBV)携带产妇血清和乳汁HBV DNA的含量,以指导母乳喂养。方法选取2008年3月至2010年1月在门诊或住院的HBV携带产妇100例,采用荧光定量PCR检测产妇血清和乳汁HBV DNA。结果 38例大三阳产妇血清和乳汁HBV DNA阳性率分别为100.0%和81.6%,39例小三阳产妇血清和乳汁中HBV DNA阳性率分别为66.7%和33.3%,23例双抗阳性产妇血清和乳汁中HBV DNA阳性率分别为30.4%和13.0%。三组间乳汁阳性率比较,大三阳产妇乳汁HBV DNA阳性率(81.6%)高于小三阳产妇(33.3%)。结论 HBV携带产妇乳汁的传染性低于血液,大三阳产妇经母乳传播HBV的概率高于小三阳产妇。乳汁中的HBV DNA阴性乙肝病毒携带产妇,建议母乳喂养,但需要动态观察,确保母乳喂养的安全。
Objective To detect the content of hepatitis B virus (HBV) carrier maternal serum and milk HBV DNA to guide breastfeeding. Methods 100 cases of HBV-carrying mothers in outpatient department or hospitalized from March 2008 to January 2010 were selected. HBV DNA of maternal serum and milk was detected by fluorescence quantitative PCR. Results The positive rates of HBV DNA in serum and milk in 38 cases of Sanyangang were 100.0% and 81.6% respectively. The positive rates of HBV DNA in serum and milk of 39 cases of Sanyangyang were 66.7% and 33.3% And breast milk HBV DNA positive rates were 30.4% and 13.0%. The positive rate of breast milk between the three groups, big Sanyang maternal milk HBV DNA positive rate (81.6%) was higher than the small Sanyang maternal (33.3%). Conclusion HBV-carrying maternal milk is less infectious than blood, and the incidence of HBV by breast-feeding in Sansanyang is higher than that in Sangyang. HBV DNA-negative hepatitis B virus in milk carries mothers and recommends breastfeeding, but requires dynamic observation to ensure the safety of breastfeeding.