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目的：研究同一膀胱癌中p53蛋白及其PCNA的表达与癌分级的关系。方法：应用免疫组化检测4例正常膀胱组织和100例膀胱癌中p53蛋白及PCNA的表达。结果：各级癌中p53蛋白阳性检出率无显著差异，p53蛋白阳性表达细胞数与癌分级呈正相关，PCNA阳性细胞数与癌分级也呈正相关。p53与PCNA阳性表达率与临床分期和术后生存率关系密切。结论：p53蛋白及PCNA的表达强度可反应膀胱癌的增殖活动和转移能力．可作为判断肿瘤发生可能性的标志物，在膀胱癌的早期诊断中有重要意义。
Objective: To study the relationship between the expression of p53 protein and PCNA and the grade of carcinoma in the same bladder cancer. Methods: Immunohistochemistry was used to detect the expression of p53 protein and PCNA in 4 cases of normal bladder tissue and 100 cases of bladder cancer. Results: There was no significant difference in the positive rate of p53 protein in all grades of cancer. The positive expression of p53 protein was positively correlated with the grade of cancer, and the positive expression of PCNA was also positively correlated with the grade of cancer. The positive rates of p53 and PCNA were closely related to clinical stage and postoperative survival rate. Conclusion: The expression of p53 protein and PCNA can reflect the proliferation and metastasis of bladder cancer. Can be used as a marker to determine the possibility of tumorigenesis, in the early diagnosis of bladder cancer is important.