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目的考察膳食结构是否对氟伐他汀治疗高胆固醇血症的药效有影响。方法半高脂饲料适应性喂养Wistar大鼠5 d,之后采取全高脂饲料喂养25 d复制大鼠高胆固醇血症模型,同时给予氟伐他汀干预,试验过程中调整不同比例高脂饲料喂养,采用全自动生化仪对多个时间段大鼠血清的总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)以及HDL-C/TC进行检测,考察氟伐他汀对高胆固醇血症大鼠模型的作用特点。结果半高脂饲料适应性饲养5 d,全高脂饲料继续喂养25 d,大鼠TC和LDL-C水平显著升高,HDL-C/TC值降低,提示高胆固醇血症大鼠模型复制成功。完全高脂饲料喂养组试验第30天以及改半高脂饲料喂养至试验第36天,血脂检测结果显示,氟伐他汀组与模型组相比,TC、LDL-C以及HDL-C/TC值组间差异无统计学意义(P>0.05)。改基础饲料喂养至试验第42天时,氟伐他汀组血清TC、LDL-C和HDL-C水平较模型组显著降低(P<0.01,P<0.05),HDL-C/TC值较对照组显著降低(P<0.05)。结论氟伐他汀对于低脂饮食结构喂养条件下的高胆固醇血症动物模型,降低血清TC和LDL-C水平效果更为显著。
Objective To investigate whether dietary structure affects the efficacy of fluvastatin in the treatment of hypercholesterolemia. Methods Wistar rats were fed with semi-high-fat diet for 5 days, then fed with full-fat diet for 25 days to make rat model of hypercholesterolemia. At the same time, fluvastatin was given to the rats. Different proportions of high fat diet were fed during the experiment. The levels of total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and HDL-C / TC in serum of rats at various time intervals were detected by automatic biochemical analyzer , Investigating the role of fluvastatin in hypercholesterolemic rat model. Results After fed with semi-high fat diet for 5 days, the rats fed with full-fat diet continued to feed for 25 days. The levels of TC and LDL-C in rats increased significantly and the HDL-C / TC decreased. This indicated that the rat model of hypercholesterolemia was successfully replicated. On the 30th day of full fat-fed diet and on the 36th day of feeding half-fat diet, the results of blood lipid test showed that TC, LDL-C and HDL-C / TC of fluvastatin group compared with model group There was no significant difference between groups (P> 0.05). Compared with the model group, the levels of TC, LDL-C and HDL-C in the fluvastatin group were significantly decreased (P <0.01, P <0.05), and the HDL-C / Decreased (P <0.05). Conclusions Fluvastatin has more significant effect on lowering serum TC and LDL-C levels in hypercholesterolemic animal models of low-fat diets.