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使用抗生素治疗已 60年之久 ,而利用药理学参数的方法使抗生素的使用更趋合理的多方面研究工作已达到了最高阶段 ,利用这些指数可以比较不同抗生素的活性 ,并对抗生素的剂量起到正确的指导作用。药动学参数 (如 :AUC、Cmax)和药效学参数 (主要为MIC)用于这一目的。对于浓度 -依赖性抗生素其药理学指数为AUC/MIC和Cmax/MIC ,而时间 -依赖性抗生素的药理学指数为T >MIC。一些作者认为指数AUC/MIC能够作为通用指数 ,但并不是所有的专家都接受这一判断。由于在文献中的各种药理学指数的定义不一致 ,因而抗感染药理学国际学会 (ISAP)公布了药动学和药效学参数和药理学指数的专用名词 ,本文将帮助确保使用一致的专用术语。另外 ,作者指出药理学指数的使用将考虑药动学差异 (患者的特性和感染部位 )和抗生素对不同病原菌 (如 :革兰氏阳性菌和革兰氏阴性菌 )的药效学差异。
The use of antibiotics has been 60 years old, and the use of pharmacological parameters to rationalize the use of antibiotics has reached its highest level in many aspects of research, using these indices to compare the activity of different antibiotics and antibiotic doses To the correct guidance. Pharmacokinetic parameters (eg AUC, Cmax) and pharmacodynamic parameters (mainly MIC) were used for this purpose. The pharmacological indices for concentration-dependent antibiotics are AUC / MIC and Cmax / MIC, whereas the time-dependent antibiotic has a pharmacological index of T> MIC. Some authors believe that index AUC / MIC can be used as a general index, but not all experts accept this judgment. Due to inconsistent definitions of various pharmacological indices in the literature, ISAP publishes jargon for pharmacokinetic and pharmacodynamic parameters and pharmacological indices, and this article will help to ensure that consistent, proprietary the term. In addition, the authors noted that the use of pharmacological indices would consider differences in pharmacokinetics (patient characteristics and site of infection) and the pharmacodynamic differences of antibiotics for different pathogens (eg Gram-positive and Gram-negative bacteria).