非经典人类白细胞抗原(HLA)-I类分子HLA-G,-E和-F在表达形式和多态性方面与经典HLA-I类分子不同。目前,这类分子在妊娠中的研究多聚焦在HLA-G;事实上,HLA-E和-F在妊娠中也起着重要的作用,可以与自然杀伤(NK)细胞的受体及T细胞受体相互作用,且均在侵入母体蜕膜的绒毛外滋养层细胞表达,是新的具有生物活性的分子。就HLA-E和-F在妊娠中的研究进展作一综述。 Non-canonical human leukocyte antigen (HLA) -I molecules HLA-G, -E, and -F differ from classical HLA-I molecules in terms of their expression patterns and polymorphisms. At present, most of the research on these molecules in pregnancy focuses on HLA-G. In fact, HLA-E and -F also play an important role in pregnancy and can interact with natural killer (NK) cell receptors and T cells Receptor interactions, and are expressed in trophoblast cells outside the villi that invade maternal decidua and are novel bioactive molecules. The research progress of HLA-E and -F in pregnancy is reviewed.