论文部分内容阅读
作者用放射免疫方法测定了10例失代偿性肝硬化并肝肾综合征、17例无氮质血症肝硬化腹水患者及50例正常人的血浆肾素活性、血管紧张素Ⅱ含量。发现肝肾综合征患者血浆肾素活性、血管紧张素Ⅱ增高极为明显,与无氮质血症的肝硬化腹水患者相比,有显著差异(P分别<0.001,0.002)。后者与正常对照相比较,其血浆肾素活性、血管紧张素Ⅱ亦有显著增高。提示肾素、血管紧张素Ⅱ在肝肾综合征的发病机理中占有一定地位。作者注意到血浆肾素活性≥20纳克/毫升的肝硬化腹水患者,腹水治疗效果差,易并发肝肾综合征。
The authors used radioimmunoassay to determine the plasma renin activity and angiotensin II level in 10 patients with decompensated cirrhosis and hepatorenal syndrome, 17 patients with azotemic ascites without cirrhosis and 50 healthy controls. We found that plasma renin activity in patients with hepatorenal syndrome, angiotensin Ⅱ increased very significantly, and no azotemia cirrhosis patients with ascites compared to significant differences (P <0.001,0.002). The latter compared with the normal control, the plasma renin activity, angiotensin Ⅱ also increased significantly. Prompt renin, angiotensin Ⅱ in the pathogenesis of hepatorenal syndrome occupy a certain position. The authors note that patients with cirrhosis and ascites with plasma renin activity ≥ 20 ng / mL have poor response to ascites and are complicated by hepatorenal syndrome.