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[目的]观察黄芪注射液+艾迪注射液联合益气清毒方干预中晚期恶性肿瘤疗效。[方法]使用随机平行对照方法,将40例住院患者按抽签法简单随机分为两组。对照组20例DCF化疗,多西紫杉醇75mg/m2,第1d静滴;5-氟尿嘧啶600mg/m2,24h内持续静滴;并加5-氟尿嘧啶2.5g~3g至化疗泵内持续点滴120h(适用于第1~5d);顺铂25mg/m2,第1~3d静滴(使用多西紫杉醇前,可常规应用甲强龙、西米替丁及非那根,以防止药物过敏)。治疗组20例1黄芪注射液10~20mL+艾迪注射液50~100mL+450mL0.9%氯化钠或5%葡萄糖,1次/d,静滴;2益气清毒方(甘草6g,陈皮10g,白术、茯苓各12g,太子参15g,藤梨根、绞股蓝各20g,半枝莲、黄芪、白花蛇舌草各30g;腹胀加木香;大便糖稀加淮山、薏苡仁;胃纳呆滞可加砂仁、神曲;大便秘结加火麻仁、杏仁;呃逆可加枇杷叶、旋覆花),1剂/d,水煎200mL,早晚口服。连续治疗30d为1疗程。观测临床症状、KPS评分、BMI指数、瘤体大小、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组临床痊愈1例,显效7例,有效10例,无效2例,总有效率90.00%。对照组临床痊愈0例,显效3例,有效8例,无效9例,总有效率55.00%。治疗组疗效优于对照组(P<0.05)。KPS评分及BMI指数治疗组优于对照组(P<0.05)。瘤体大小两组间无明显差异(P>0.05)。[结论]黄芪注射液+艾迪注射液联合益气清毒方干预中晚期恶性肿瘤效果显著,值得推广。
[Objective] To observe the curative effect of Huangqi injection + Aidi injection combined with Yiqi Qingdu prescription on intervening malignant tumors. [Methods] Randomized parallel control method was used to randomly divide 40 inpatients into two groups by lottery. In the control group, 20 cases of DCF chemotherapy, docetaxel 75mg/m2, 1d intravenous infusion; 5-fluorouracil 600mg/m2, continuous infusion within 24h; plus 5-fluorouracil 2.5g~3g to continue drip in the chemotherapy pump for 120h (applicable In the first 1 ~ 5d); cisplatin 25mg/m2, 1 ~ 3d intravenous infusion (before the use of docetaxel, conventional application of methylprednisolone, cimetidine and phenazine, to prevent drug allergies). The treatment group of 20 cases of astragalus injection 10 ~ 20mL + Aidi injection 50 ~ 100mL +450mL0.9% sodium chloride or 5% glucose, 1 times / d, intravenous infusion; 2 Yiqi Qingdu side (licorice 6g, orange peel 10g, Atractylodes, Poria each 12g, heterophylla 15g, vine root, Gynostemma each 20g, Scutellaria barbata, Astragalus membranaceus, Hedyotis diffusa each 30g; abdominal distension and woody incense; stool sugar dilute yam, Coix seed; appetite can be sluggish Add Amomum villosum, Divine Comedy; Constipation plus hemp seed, almonds; Hiccup can add loquat leaves, inverted flowers), 1 agent / d, 200mL water, sooner or later oral. Continuous treatment for 30d is a course of treatment. Observed clinical symptoms, KPS score, BMI index, tumor size, adverse reactions. Continuous treatment of 2 courses to determine efficacy. [Results] In the treatment group, one case was cured, 7 cases were markedly effective, 10 cases were effective, 2 cases were ineffective, and the total effective rate was 90.00%. In the control group, 0 cases were cured, 3 cases were markedly effective, 8 cases were effective, 9 cases were ineffective, and the total effective rate was 55.00%. The therapeutic effect of the treatment group was better than that of the control group (P<0.05). The KPS score and BMI index were better in the treatment group than in the control group (P<0.05). There was no significant difference in tumor size between the two groups (P>0.05). [Conclusion] Huangqi Injection + Aidi Injection combined with Yiqi Qingdu Recipe has significant effects on the treatment of advanced malignant tumors, which deserves promotion.