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目的检测食物过敏(FA)婴儿和健康婴儿的主要肠道菌群,为食物过敏与肠道菌群关系研究提供线索。方法采用病例对照研究,检测2003年5～12月在重庆医科大学儿童医院儿保门诊体检的52例FA婴儿和100例健康婴儿的大便菌群(双歧杆菌属、乳酸杆菌属、肠杆菌科),大便菌群的分析采用GLM的广义析因法。结果FA婴儿大便双歧杆菌计数减少[(9.61±1.16)VS(10.31±1.20)Log10CFU/g,P<0.001],肠杆菌计数增多[(9.54±0.60)VS(9.07±0.64)Log10CFU/g,P<0.001]。不同喂养方式下FA婴儿大便的肠道菌群改变相似。结论食物过敏婴儿肠道菌群与健康婴儿的肠道菌群存在显著差别。
Objective To detect the main gut flora in food allergy (FA) infants and healthy infants, and provide clues for the relationship between food allergy and intestinal flora. Methods A case-control study was conducted to detect the stool flora (Bifidobacterium, Lactobacillus, Enterobacteriaceae) of 52 FA infants and 100 healthy infants from May to December 2003 in Children’s Hospital of Chongqing Medical University ), The analysis of stool flora using the GLM’s general factoring. Results Compared with the control group, the number of Bifidobacterium pallidum in FA infants was significantly lower than that in the control group ([(9.61 ± 1.16) vs (10.31 ± 1.20) Log10CFU / g, P <0.001] P <0.001]. The intestinal microflora changes of FA baby stools under different feeding modes were similar. Conclusion There is a significant difference in gut microbiota between healthy children and food allergy infants.