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目的探讨尼群地平联合卡托普利治疗小儿急性肾小球肾炎性高血压的疗效及安全性。方法将84例患儿随机分为治疗组40例和对照组44例。治疗组给予小剂量尼群地平联合卡托普利,对照组给予利血平治疗。结果治疗组显效32例,有效8例,总有效率100%;对照组显效10例,有效22例,无效10例,总有效率77.27%。结论尼群地平联合卡托普利治疗小儿急性肾小球肾炎性高血压疗效显著,口服吸收好,无明显不良反应。
Objective To investigate the efficacy and safety of nitrendipine combined with captopril in the treatment of children with acute glomerulonephritis-induced hypertension. Methods Eighty-four children were randomly divided into treatment group (n = 40) and control group (n = 44). The treatment group was given a small dose of nitrendipine combined captopril, the control group was treated with reserpine. Results The treatment group 32 cases markedly effective in 8 cases, the total effective rate was 100%; the control group markedly effective in 10 cases, effective in 22 cases, ineffective in 10 cases, the total effective rate was 77.27%. Conclusion Nitrendipine combined with captopril treatment of acute renal glomerulonephritis in children with significant effect, oral absorption, no significant adverse reactions.