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酒精是否致癌是人们非常关注的问题,早在1964年世界卫生组织就提出,饮酒与口腔、喉和食道等肿瘤的发生有密切关系。近20年来人们对酒精与肿瘤的关系又有了许多新的认识。现仅就酒精与肿瘤发病机理方面的有关进展做一综述。一、酒精诱导微粒体细胞色素P_(450)酶系统生物转化 90%以上的环境致癌物都是以致癌物原形存在,需经体内微粒体细胞色素P_(450)酶系统激活才具有致癌性。当活化的致癌物与细胞内大分子如DNA、RNA或蛋白结合后,就有可能诱发基因突变而致癌。例如检测致癌物的
Whether alcohol causes cancer or not is a matter of great concern to the public. As early as 1964, the World Health Organization proposed that drinking alcohol is closely related to the occurrence of tumors such as the mouth, throat and esophagus. In the past 20 years, people have gained new insights into the relationship between alcohol and cancer. Only a review of the progress made in the pathogenesis of alcohol and cancer is presented. First, alcohol-induced microsomal cytochrome P_ (450) enzyme system biotransformation More than 90% of environmental carcinogens are present in the original form of carcinogens, the body must be activated by microsomal cytochrome P_ (450) enzyme system to have carcinogenicity. When activated carcinogens bind to intracellular macromolecules such as DNA, RNA, or proteins, they may induce genetic mutations that cause cancer. For example, for detecting carcinogens