葡萄糖-6-磷酸酶是肝脏糖异生的两个关键酶之一,该酶的活性变化直接影响肝脏葡萄糖的输出。大量的研究表明,葡萄糖-6-磷酸酶的活性及其基因表达水平在胰岛素抵抗、糖尿病中均明显增加。因此,该酶同胰岛素抵抗、糖尿病高血糖有着密切的关联。葡萄糖-6-磷酸酶作为糖尿病治疗药物的一个潜在靶点正日益成为人们研究的重点。 Glucose-6-phosphatase is one of the two key enzymes of hepatic gluconeogenesis, and the changes of the enzyme’s activity directly affect the output of hepatic glucose. A large number of studies have shown that glucose-6-phosphatase activity and gene expression levels were significantly increased in insulin resistance, diabetes. Therefore, the enzyme with insulin resistance, diabetes, hyperglycemia are closely linked. Glucose-6-phosphatase as a potential therapeutic target for diabetes is increasingly becoming the focus of research.