The pathophysiology of neuropathic pain in Fabry’s disease (FD) is still larg ely unknown. Seven FD patients were studied by laser evoked potentials (LEPs) to assess the function of the Aδ.and C fibers. Laser pulses were delivered on the skin of the hand and perioral region at painful intensity to record LEPs relate d to Aδfiber inputs and at nonpainful intensity to obtain LEPs related to Cfi ber inputs. When the perioral region was stimulated, a vertex positive component was recorded with a mean latency of 260.3 ms and 376 ms after Aδand Cfiber stimulation, respectively. The mean AδLEP amplitude was significantly lower in FD patients (N1/P1 mean values were 2.8 μV and 4.5 μV after hand and face s timulation, respectively, compared to 4 μV and 8.9 μV for controls; N2/P2 mean values were 8.2 μV and 11.1 μV after hand and face stimulation, respectively, and 16.7 μV and 22.3 μV in controls). Unlike the healthy subjects, 6 FD patie nts, suffering from neuropathic pain, showed a late positive potential related t o Cfiber function (mean latency, 377.1 ms) also after facia l stimulation at painful intensity, suggesting a relative overflow of Cfiber i nput, which may be relevant in the pathophysiology of pain in this disease. The pathophysiology of neuropathic pain in Fabry’s disease (FD) is still larg ely unknown. Seven FD patients were studied by laser evoked potentials (LEPs) to assess the function of the Aδ.and C fibers. Laser pulses were delivered on the skin of the hand and perioral region at painful intensity to record LEPs relate d to Aδfiber inputs and at nonpainful intensity to obtain LEPs related to Cfi ber inputs. When the perioral region was stimulated, a vertex positive component was recorded with a mean latency of 260.3 ms and 376 ms after Aδand Cfiber stimulation, respectively. The mean AδLEP amplitude was significantly lower in FD patients (N1 / P1 mean values ​​were 2.8 μV and 4.5 μV after hand and face stimulation, respectively, compared to 4 μV and 8.9 μV for controls; N2 / P2 mean values ​​were 8.2 μV and 11.1 μV after hand and face stimulation, respectively, and 16.7 μV and 22.3 μV in controls.) Unlike the healthy subjects, 6 FD patients, suffering from neuropathic pain, showed a late positive potential related to Cfiber function (mean latency, 377.1 ms) also after facia l stimulation at painful intensity, suggesting a relative overflow of Cfiber i nput, which may be relevant in the pathophysiology of pain in this disease.