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观察重复＋１０Ｇｚ暴露对大鼠脑脂质过氧化反应和肝肾功能的影响以及天然抗氧化剂茶多酚（ＴＰ）的防护作用。方法２４只雄性Ｗｉｓｔａｒ大鼠随机等分为三组（ｎ＝８）：Ａ组（对照组），Ｂ组（＋１０Ｇｚ组）和Ｃ组（ＴＰ组）。Ｂ、Ｃ组重复＋１０Ｇｚ暴露（每次３０ｓ，Ｇ增长率约为０．５Ｇ／ｓ，３次／ｄ，间隔＋１Ｇｚ１ｍｉｎ，３ｄ／ｗｋ，共４ｗｋ），而Ａ组仅受＋１Ｇｚ作用。Ｃ组于＋Ｇｚ实验前约１ｈ灌胃给予ＴＰ（２００ｍｇ／ｋｇ），另外两组给予等量蒸馏水。测定脑脂质过氧化反应、肝肾功能和血脂水平。结果与对照组相比，Ｂ组大脑皮层匀浆、线粒体和胞浆脂质过氧化反应明显增强（Ｐ＜０．０５），血浆肌酐水平明显升高（Ｐ＜０．０１）；而ＴＰ对此过氧化反应具有显著抑制作用并明显降低血浆肌酐水平。各组间血清谷丙转氨酶活性、甘油三酯和总胆固醇水平无统计学差异。结论重复高＋Ｇｚ作用可引起脑自由基损伤并损害肾功能，而天然抗氧化剂茶多酚具有明显的保护作用。
To observe the effects of repeated +10 Gz exposure on lipid peroxidation and liver and kidney function in rats brain and the protective effect of natural antioxidant tea polyphenols (TP). Methods Twenty-four male Wistar rats were randomly divided into three groups (n = 8): A group (control group), B group (+10 Gz group) and C group (TP group). Groups B and C were exposed to + 10Gz repetitions (30s each time, G increased approximately 0.5G / s, 3 times / d, intervals + 1Gz1min, 3d / wk, total 4wk), while group A was affected by + 1Gz only. Group C was fed with TP (200 mg / kg) orally at about 1 h before the + Gz test, and the other two groups were given the same amount of distilled water. Determination of lipid peroxidation, liver and kidney function and blood lipid levels. Results Compared with the control group, the lipid peroxidation of mitochondria and mitochondria in group B was significantly increased (P <0.05) and the level of plasma creatinine was significantly increased in group B (P <0.01) This peroxidation has a significant inhibitory effect and significantly reduces plasma creatinine levels. Serum alanine aminotransferase activity, triglyceride and total cholesterol levels between the two groups showed no significant difference. Conclusion Repeated high + Gz can cause damage to brain free radicals and impair renal function, while natural antioxidant tea polyphenols has obvious protective effect.