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利用离体大鼠肾灌流模型研究了ＦＫ５０６的肾毒性，ＦＫ５０６的灌流浓度分别为１０－８ｍｏｌ／Ｌ、１０－６ｍｏｌ／Ｌ、及１０－５ｍｏｌ／Ｌ。结果显示：１０－５ｍｏｌ／Ｌ的ＦＫ５０６灌流后肾灌流阻力、灌流量及肾小球滤过率均有明显改变，１５ｍｉｎ、３０ｍｉｎ及４５ｍｉｎ三指标分别上升或下降２２．２％～３２．５％，与基础值及对照组相比均有显著性差异（Ｐ＜０．０１～Ｐ＜０．００１）。结果同时显示短期灌流后对钠、水回吸收无影响。作者认为ＦＫ５０６对肾脏的急性作用主要影响肾血管。Ｐ＜０．００１；组间比较△Ｐ＜０．０１．△△Ｐ＜０．００１２．３不同浓度ＦＫ５０６对钠及水回吸收的影响 由表２可见，用１０－８ｍｏｌ／Ｌ、１０－６ｍｏｌ／Ｌ、及１０－５ｍｏｌ／Ｌ的ＦＫ５０６灌流后水的回吸收略有增加，但无统计学意义。表２不同浓度ＦＫ５０６对肾钠、水回吸收分数的影响组间组内比较均无显著差异２．４不同浓度ＦＫ５０６对肾灌流阻力的影响由表３可见，用１０－５ｍｏｌ／ＬＦＫ５０６灌流后，肾灌流阻力明显上升，１５ｍｉｎ、３０ｍｉｎ及４５ｍｉｎ分别上升２６．５％、２５％及２９％。与对照组及同组基础值相比差异有显著性（Ｐ均＜０．０１）。表３不同浓?
The nephrotoxicity of FK506 was studied by using rat renal perfusion model. FK506 perfusion concentration was 10-8mol / L, 10-6mol / L, and 10-5mol / L, respectively. The results showed that after perfusion with 10-5mol / L FK506, the perfusion resistance, perfusion and glomerular filtration rate obviously changed. The three indexes of 15min, 30min and 45min respectively increased or decreased by 22.2% -32.5% (P <0.01 ~ P <0.001) compared with the baseline and control group. The results also showed that after short-term perfusion of sodium, water no effect on absorption. The author believes that the acute effects of FK506 on the kidneys mainly affect the renal vessels. P <0.001; comparison between groups △ P <0.01. △ △ P <0.0012.3 Effect of different concentrations of FK506 on the absorption of sodium and water As can be seen from Table 2, after water was infused with 10-8 mol / L, 10-6 mol / L and 10-5 mol / L of FK506 Back absorption increased slightly, but not statistically significant. Table 2 different concentrations of FK506 renal sodium, water absorption fraction of intra-group differences were not significantly different 2.4 different concentrations of FK506 renal perfusion resistance can be seen from Table 3, with 10-5mol / LFK506 perfusion, Kidney perfusion resistance increased significantly, 15min, 30min and 45min increased by 26.5%, 25% and 29%. Compared with the control group and the same group, the difference was significant (P <0.01). Table 3 different concentrations?