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目的探讨尿道内尖锐湿疣患者行光动力治疗前口服布洛芬缓释胶囊对治疗疼痛的缓解作用。方法 153例尿道内尖锐湿疣患者随机分为观察组78例和对照组75例,2组均给予5-盐酸氨酮戊酸-光动力疗法(5-aminolevulinic acid-photodynamic therapy,ALA-PDT)治疗,每次照射20 min,每7~10d重复1次,共治疗3次;观察组在每次ALA-PDT治疗前30min口服布洛芬缓释胶囊0.3g。分别于光照5min及治疗完成后30 min行线性视觉模拟评分(visual analog scale,VAS);于治疗完成后2周评估疣体完全清除率,6个月评估复发率,并进行比较。结果观察组、对照组疣体完全清除率分别为85.9%和84.0%,复发率分别为14.9%和12.5%,2组比较差异均无统计学意义(P>0.05);治疗5min及治疗完成后30min观察组VAS评分(4.55±1.07、2.09±0.74)均低于对照组(5.57±1.08、3.32±0.97),差异有统计学意义(P<0.05)。结论尿道内尖锐湿疣患者行ALA-PDT治疗前30min口服布洛芬缓释胶囊可缓解ALA-PDT治疗疼痛,且不影响治疗效果。
Objective To investigate the relieving effect of oral ibuprofen sustained-release capsules before photodynamic therapy on the treatment of pain in patients with urethral condyloma acuminatum. Methods 153 cases of urethral condyloma acuminatum were randomly divided into observation group (78 cases) and control group (75 cases). Both groups were given 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) , Each irradiation 20 min, every 7 ~ 10d repeat 1 times, a total of three times treatment; observation group 30 minutes before each ALA-PDT oral ibuprofen sustained release capsules 0.3g. Linear visual analog scale (VAS) was performed at 5 min after irradiation and 30 min after treatment, respectively. Complete wart clearance was assessed 2 weeks after the completion of treatment, and the recurrence rate was evaluated at 6 months. Results The complete removal rates of wart in observation group and control group were 85.9% and 84.0% respectively, the recurrence rates were 14.9% and 12.5% respectively. There was no significant difference between the two groups (P> 0.05) The VAS scores in the 30 min observation group (4.55 ± 1.07,2.09 ± 0.74) were significantly lower than those in the control group (5.57 ± 1.08 and 3.32 ± 0.97, respectively) (P <0.05). Conclusion Patients with urethral condyloma acuminatum treated with ALA-PDT 30 min before oral administration of ibuprofen sustained release capsules can relieve the pain of ALA-PDT, and does not affect the therapeutic effect.