脑水肿是指脑组织内的异常水分潴留,使脑体积增大,是多种疾病伴发的一种病理状态。脑水肿的非手术治疗的方法有渗透性利尿、高张盐水,亚低温治疗等,尚没有针对脑水肿分子机制的有效治疗。水通道蛋白(AQP)是膜水通道蛋白家族,为调节跨细胞水平衡的选择性孔道,迄今在哺乳动物中已 Cerebral edema refers to the abnormal water retention in the brain tissue, so that brain volume increases, is a pathological state associated with a variety of diseases. Non-surgical treatment of cerebral edema methods include osmotic diuresis, hypertonic saline, mild hypothermia treatment, there is no effective treatment for molecular mechanisms of cerebral edema. Aquaporin (AQP), a membrane aquaporin family, is a selective pore that regulates the balance of cellular water, so far in mammals