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目的了解新疆肥胖儿童高胰岛素血症及糖耐量异常的情况。方法 2007年5月~2014年4月因肥胖在新疆维吾尔自治区人民医院儿科就诊且资料完整的儿童55例,做口服葡萄糖耐量试验(OGTT),先测空腹血糖及胰岛素,口服葡萄糖后1/2、1、2、3h分别测血糖及胰岛素;血糖采用葡萄糖氧化酶法测定,胰岛素采用化学发光法测定。结果 55例肥胖儿童中有41.8%(23/55)患者高胰岛素血症,43.6%(24/55)存在糖耐量受损,仅1.8%(1/55)存在空腹血糖受损,肥胖儿童高胰岛素血症及糖耐量受损的发生率明显高于空腹血糖受损的发生率,差异有统计学意义(χ2=29.792,P<0.05)。结论新疆肥胖儿童高胰岛素血症及糖耐量受损发生率较高;肥胖儿童不能仅检测空腹血糖,做葡萄糖耐量试验才能反映患儿糖代谢的真实情况。
Objective To understand the hyperinsulinemia and impaired glucose tolerance in obese children in Xinjiang. Methods From May 2007 to April 2014, 55 children with obesity who were admitted to Pediatrics Hospital of People’s Hospital of Xinjiang Uygur Autonomous Region for oral glucose tolerance test (OGTT) were enrolled in this study. The fasting blood glucose, insulin and oral glucose 1/2 , 1,2,3h were measured blood glucose and insulin; glucose using glucose oxidase method, the determination of insulin by chemiluminescence method. Results Hyperlipemia was found in 41.8% (23/55) of 55 obese children, with impaired glucose tolerance in 43.6% (24/55), impaired fasting glucose in only 1.8% (1/55), and high in obese children The incidence of insulinemia and impaired glucose tolerance was significantly higher than that of impaired fasting glucose (χ2 = 29.792, P <0.05). Conclusion The incidence of hyperinsulinemia and impaired glucose tolerance in obese children in Xinjiang is relatively high. Obese children can not only detect fasting blood glucose, so glucose tolerance test can reflect the real situation of children with glucose metabolism.