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原发性胆汁性肝硬化(简称PBC)与慢性活动性肝炎有许多共同之处,随着PBC病程的进展,炎性浸润日益弥漫,最终导致肝硬化。在有些病例,炎性浸润超越汇管区限板,引起汇管周围肝细胞碎屑样坏死,犹如慢性活动性肝炎。在慢性活动性肝炎,汇管周围肝细胞损伤伴有抗肝脏特异性细胞膜脂蛋白(LSP)的细胞免疫和体液免疫反应,肝细胞的损害可能即由此而引起。文献上曾有在少数PBC病人发现同样结果的报道,但所用的测定方法麻烦,且不敏感。本文报道采用放射免疫测定法对37例PBC测定其抗LSP抗体的水平,并与肝脏活检的组织学变化进行对比分析。37例中女29例,男8例,均经组织学、生化以及免疫检查确定为PBC。根据肝活检所示淋巴细胞及浆细胞在汇管区浸
Primary biliary cirrhosis (referred to as PBC) and chronic active hepatitis have many common features, with the progress of PBC disease, inflammatory infiltration is increasingly diffuse, eventually leading to cirrhosis. In some cases, inflammatory infiltrates go beyond the confluence of the portal area, causing detrusor-like necrosis of hepatocytes around the portal vein, just like chronic active hepatitis. In chronic active hepatitis, hepatocellular injury around the portal is accompanied by cellular and humoral immune responses against liver-specific membrane lipoprotein (LSP), which may result from the damage of hepatocytes. There have been reports in the literature of the same results found in a small number of PBC patients, but the assay was cumbersome and insensitive. This article reports the use of radioimmunoassay in 37 cases of PBC determination of anti-LSP antibody levels, and liver biopsy histological changes were compared. 37 cases of female 29 cases, 8 males, were histologically, biochemical and immune examination identified as PBC. According to liver biopsy showed lymphocytes and plasma cells in the portal area immersion